Human Breast Epithelial Cells
Human Breast Epithelial Cells In 3-Dimensional Culture Form Organized And Polar Structures
As in this image, non-malignant breast epithelial cells form polar structures that resemble the ‘acini’ that exist in vivo. This occurs in 3-dimensional extracellular matrix gels
that contain a high concentration of the basement membrane molecule laminin iii. However, cancerous breast cells form tumor-like structures in the same gels, making this an
easy assay to distinguish normal and malignant cells.
The assay was developed in the laboratories of Petersen and Bissell (PNAS, 1992).
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